There are many roads to Rome but ultimately the goal is to get the destination. You can take different roads depending on your circumstances and constraints.
If time is no consideration then take the scenic route, stop and see the sites and by all means sample the cuisine along the way. If time is limited then a direct route is necessary and the route must be carefully planned, there is little margin for error. Stops must be carefully planned and programmed for efficiency. It can help if you have been there before, that can give some margin for error but never take anything for granted as conditions may have changed. The moral is that if you want to get to Rome have a current road map or working GPS, get help from someone who has been there before and understand the constraints that can limit you ability to get there in the desired time.